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Male C57BL/6 mice (78 weeks old, 2528 g) were purchased from the Institute of Laboratory Animal Science at the Chinese Academy of Medical Sciences (Beijing, China) and housed in a specific pathogen-free facility maintained at 2022 C, with cycles of 12 h light-dark and food and water ad libitum

Roles of NNMT in Energy Metabolism and the Related Mechanisms As a precursor of NAD + , NA methylation plays important roles in regulating energy metabolism because methylated NA is no longer able to be salvaged into NAD + [16]

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analyzed the intervention effects of Dioscorea extract on aging rats with chronic atrophic gastritis based on the Shh pathway and found that Dioscorea extract regulated the secretion of gastric juice, gastric acid, and pepsin, while inhibiting the progression of the disease (Li et al., 2017)