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There was also a statistically significant lower adjusted mean change from baseline to week 48 in the fatigue impact scale score for the teriflunomide 7 mg arm as compared to the interferon beta-1a 44 mcg arm (p=0.03), but not for the teriflunomide 14 mg arm as compared to the interferon beta-1a 44 mcg arm (p=0.18)

Acute ischaemic stroke mixed, leaning cautious The 2023 Cochrane review found no clear clinical benefit and a moderate-certainty signal of more non-fatal serious adverse events