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Figure 2 SCFAs can also modulate the gut-brain axis by influencing the production of gut hormones such as GLP-1 and PYY, which have neuroprotective effects and regulate appetite and energy homeostasis, as previously described (Lai et al., 2024)

Together, these findings indicate that while strong oxidants, such as H 2 O 2 , favor irreversible thiol overoxidation and suppress disulfide chemistry, reactive nitrogen species provide a physiologically relevant pathway for disulphide cross-linking of TTR

Furthermore, studies have demonstrated that Polydatin [163] and quercetin [164] suppress TLR4/NF-B signaling in NASH modelsthe former by inhibiting CD68 macrophage activation in MCD-diet mice, the latter via reversing endotoxin translocation from dysbiotic microbiota in HFD-fed mice, with quercetin concurrently inhibiting NLRP3 inflammasome and ER stress to normalize lipid metabolism genes