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ALCAR was either administered orally (4 g/day for 90 days) in four trials or intravenously (4 g/day for three days) in one trial

Deficiency develops gradually, as the body stores approximately 2-5 mg of B12 in the liver, which can sustain normal function for several years even with inadequate intake or absorption

The injectable 500 mg/mL solution bypasses the gut, which sidesteps the absorption-driven GI complaints of oral dosing but injection carries its own generic considerations, the local injection-site reactions (pain, redness, irritation) common to any intramuscular or subcutaneous injection

doi: 10.1126/science.1181928 224 SubraCGrandDLaulagnierKStellaALambeauGPaillasseMet al