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The fusion peptide demonstrated sleep-promoting effects, influenced neurotransmitter levels (5-HT, glutamate, dopamine, melatonin), and confirmed that the Tat cell-penetrating sequence was the more effective BBB carrier of two tested candidates establishing DSIP as a validated active scaffold for BBB-crossing fusion peptide sleep research and supporting the development of next-generation DSIP-based neuromodulatory tools

Moreover, technical limitations involve challenges in accurately delivering stem cells to the exact location of the burst fracture and ensuring their retention and survival at the injury site