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Repetitive apneas as observed in SA syndrome are associated with increased diurnal drowsiness, neurocognitive dysfunction, and cardiovascular morbidity (Young et al., 2002
Based on the Vd, you can calculate precisely how much additional phenobarbital is required in a top-up dose to hit the therapeutic target
Emerg Infect Dis 22:511 Murthy AR, Marulappa R, Hegde U, Kappadi D, Ambikathanaya U, Nair P (2015) Treatment guidelines and prognosis of immune reconstitution inflammatory syndrome patients: a review
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