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Chronic high-dose pyridoxine can cause sensory neuropathymanifesting as numbness, tingling, or gait instabilityemphasizing the need for appropriate dosing and periodic reassessment

(B) The average recovery of total radioactivity in the urine, feces, cage cleaning uid, and cadavers during 072 h after [ 3 H] BPC157 administration in intact rats (mean SD, n=6).(C) The average recovery of total radioactivity in the urine, feces, and cage cleaning uid collected during 072 h after [ 3 H]BPC157 administration in bile duct cannulated rats (mean SD, n=6).(D) Total radioactivity concentration versus time curve for [ 3 H]BPC157 in jugular vein cannulated rats following a single intramuscular injection at a dose of 100 g/300 Ci/kg (mean SD, n= 6)

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However, researchers have found that changes in the angle of impact can also affect the nature of brain injuries and the resulting skull fractures [119, 175]