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It is important to take into consideration that though intravenous glutathione is considered to increase its efficacy, it can also pose the risk of overdosing and toxicity (3)

-glutamyl transpeptidase (GGT), the enzyme responsible for GSH degradation, is located on the external surface of epithelial cells in kidney tubules, biliary epithelium and brain capillaries, allowing GSH amino acidic constituents to be recycled in the so-called -glutamyl cycle for intracellular GSH synthesis [25]

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[33], who highlighted that l-methionine induced an endogenous antioxidant response to suppress ROS-derived oxidative stress