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Finally, emerging evidence suggests BAT is an integrated metabolic tissue with endocrine functions (Villarroya et al., 2017) and roles in glucose homeostasis (Li et al., 2021)

These various routes underscore the complex metabolic landscape for APOA1 metabolism in the liver, where remodeled HDL particles or APOA1 are processed for additional lipid transport through recycling and secretion into the circulation

Chronic hepatitis C can lead to cirrhosis and hepatocellular carcinoma (HCC), followed by death in about 5% of individuals (Stanaway et al., 2016)

In children, hyperammonemia is mainly caused by severe liver failure and inborn errors of metabolism
