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BDNF binding to TrkB triggers autophosphorylation of the tyrosine residue in its intracellular domain, leading to ligand-induced dimerization in each receptor, which activates several intracellular signalling pathways with various functions (32)

Furthermore, the blood circulation results on 4T1 bearing mouse xenograft model have shown to follow two-compartment model showing first and second half-life of 2.65 and 35.3 h, respectively