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Data acquisition was performed using version 7 of pClamp software (Axon Instruments)

Metabolite treatment increased the endogenous levels of individual treated metabolites in each treatment group compared to the control group (Supplementary Fig

Numerous phase contrast images were collected (at 10 magnification, and with a scale bar of 200 m) at different time points (of 4 h or 24 h post transfection (p.t.), or at 24 h or 48 h p.i.) from each group

However, these outcomes rarely align with clinically meaningful endpoints such as probing depth reduction, clinical attachment gain, tooth mobility stabilization, longterm tooth retention, or patientreported measures like pain and quality of life