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Understanding the intricacies of p53 regulation and the consequences of its mutations is essential for developing effective diagnostic and therapeutic strategies in hematological malignancies, ultimately enhancing patient care and survival

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Treatment of micrometastatic disease is the principal underlying adjuvant therapy in patients without evident metastatic disease after surgery, which has improved the cure rate for multiple cancers, but it has been difficult to demonstrate benefit from alternate use of non-crossresistant drugs

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