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Osteosarcoma is the most frequent bone tumor in children and adolescents and was reported in adults who were treated with GH in childhood

Identifying the structural determinants of the ligand-stimulated transport of GSH by MRP1 is critical to understand the mechanism by which MRP1 regulates the GSH homeostasis and to allow the design of future CS agents that can selectively kill MRP1-overexpressing chemoresistant cancer cells

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