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The shock moved the pin by a matter of millimeters

Ann Neurol 1995

This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification

These neurophathologies are characterised by confusion, poor memory, eye muscle paralysis (nystagmus) and problems with muscle coordination (Shible et al, 2019)