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Neurological and Neurodegenerative Conditions Neurological applications remain highly preliminary based on animal model studies

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Also, in an experimental model of ischemia-reperfusion aimed to investigate the effect of CR on mitochondrial function and subsequent molecular mechanisms of CR-induced cardioprotection, a significant reduction of mitochondrial oxidative stress (H 2 O 2 ) in cardiac samples isolated from the CR group (6 months) (Shinmura et al., 2011)