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Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2011

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Activation of PI3K/Akt pathway is essential for GSB-106-mediated neuroprotection TrkB-dependent activation of the PI3K/Akt cascade regulates number of proteins essential for neuronal survival, growth and differentiation such as GSK-3 (glycogen synthase kinase 3) and certain substrates that directly regulate the caspase cascade, in particular, the proapoptotic factorBAD (Bcl-2 antagonist of cell death) 34

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