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Factors such as trauma, nutritional deficiencies, irritable bowel disorders, leaky gut, microbiome dysbiosis, and immune dysregulation can all contribute to the generation of ROS, leading to tissue damage and ulcer formation

Fertility was normal in the offspring of mice exposed daily from before birth ( in utero ) through sexual maturity at daily exposures (AUC) of approximately 60 times higher than human exposures at the recommended 200 mg daily dose

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