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Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells
This explains why also in aerobic conditions, glycolysis is heavily used by cells with a high anabolic need (i.e., a need of building blocks for the biosynthesis of nucleotides, lipids or proteins), even despite that such aerobic glycolysis (i.e., the conversion of glucose into pyruvate and subsequently lactate in the cytoplasm) is much less efficient in ATP generation compared to shuttling glucose-derived pyruvate to mitochondrial respiration (i.e., into the TCA/OXPHOS cycle)
A correlation has been established in elderly individuals between reduced nocturnal melatonin secretion and hypertension [97]
