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Thus, the human requirement for choline is especially influenced by the relationship between choline and other methyl group donors, such as folate and S-adenosylmethionine

L.CioccariL.BitkerL.PeckL.YoungH.et al (2020)
PLCepsilon knockdown inhibits prostate cancer cell proliferation via suppression of Notch signalling and nuclear translocation of the androgen receptor
It can be more difficult to manage and it is too great a health risk to take when there is a safer alternative for CV treatment