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As observed in the brain, also in peripheral AD samples, the analysis of SOD is controversial, and some authors found significantly lower erythrocyte and plasma/serum levels whereas others found significantly higher erythrocyte or plasma levels (378, 379)

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However, LPCAT3 is not required for ferroptosis induction.31 Both, non-enzymatic (Fenton chemistry) and enzymatic (lipoxygenases, LOXs) mechanisms may trigger lipid peroxidation.33,34 However, the specific contribution of each mechanism is unclear and it may differ for different ferroptosis inducers.34 At which regulatory point iron contributes to ferroptosis is unclear

Early recognition and proper treatment can improve patient's outcome References: [1] Comparative study: Side effects of Folfox4 and folfiri for colorectal cancer chemotherapy regiment in Margono Soekarjo Hospital, Purwokerto Wiratama, I.N.A