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Description
Purging typically resolves, with improvement following

Feeling hot or cold Unusual hunger and weight gain Dry mouth Fatigue and dizziness Heart problems such as abnormal rhythms Blood pressure changes (increase or decrease) Anecdotal side effects Anxiety and loss of sleep (Taking in AM and early afternoon helped (having doses around 250-350mg))

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Consequently, the brain/plasma ratio was the highest for MTX-N-ISG, indicating improved brain-targeting efficiency with few systemic adverse effects
