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Description
Phase II conjugation reactions which generally act follow phase I activation consists of reactions in which metabolites containing appropriate functional groups are conjugated with substances such as glucuronate, glutamate, sulfate, reduced glutathione or uridine diphosphate (UDP)-glucuronic acid to finally discharge them through urine or bile

Increased HIF-1 activity stimulates ASCT2 transcription alongside other amino acid transporters to boost glutamine uptake which supports cell survival and proliferation within hypoxic tumor settings
Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria

Russmann et al
