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In these tumors, CHAC1can promote tumor cell survival, proliferation, and invasion, contributing to cancer progression and drug resistance
In addition, cyclin E- and A-dependent Cdk complexes phosphorylate and inhibit the E3 ubiquitin ligase APC/C activating subunit Cdh1, stabilizing APC/C Cdh1 substrates, including cyclin A (Di Fiore et al., 2015
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