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In addition, the increasing of oxidative and nitrosative stress in the heart during aging and the decreasing of hydrogen sulfide (H 2 S) concentration along with a decline of a constitutive synthesis of nitric oxide (NO) collectively lead to the dysfunction of mitochondrial mechanisms, in particular to the formation of a non-selective channelsthe mitochondrial permeability transition pores (mPTP) in the high-conductance mode, which is the cause of many pathological conditions (Strutynska et al., 2016
Obecne ograniczenia bada obejmuj brak wielkoskalowych randomizowanych bada klinicznych u ludzi, wci niepene zrozumienie precyzyjnych mechanizmw molekularnych oraz brak szczegowych danych farmakokinetycznych u ludzi
Trends in Plant Science 20, 807813
193(3 Pt 1): 771777
