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Moreover, two main types of receptor-mediated mitophagy pathway have been classified as follows in brief: ubiquitin-independent mitophagy receptors, including BCL2-interacting protein 3 (BNIP3) (Quinsay et al., 2010), BCL2-interacting protein 3 like (NIX/BNIP3L) (Sandoval et al., 2008), FUN14 domain-containing 1 (FUNDC1) (Liu et al., 2012), BCL2-like 13 (BCL2L13) (Otsu et al., 2015), autophagy and beclin 1 regulator 1 (AMBRA1) (Strappazzon et al., 2015), FKBP prolyl isomerase 8 (FKBP8) (Wei et al., 2017), and NLR family member X1 (NLRX1) (Zhang et al., 2019)

It is possible that the evidence presented above concerning preventing dark adaptation in the diabetic retina, may also apply to other retinal conditions in which anti-VEGF drugs have been shown to be beneficial: Retinal diseases such as wet age related macular degeneration (257-265) (see chapter on age related macular degeneration (AMD) in Webvision ) and retinopathy of prematurity (266)

Stimulated saliva flow was obtained between 8:30 and 9:00a.m