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Here this group reports a ruthenium-based nanocatalyst alleviating hypoxic TME, activating protein transient receptor potential melastatin 2 ion channel, promoting systemic immune response thereby eliciting its therapeutic efficacy against osteosarcoma.

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Additionally, magnesium supplementation has shown potential benefits when combined with metformin, enhancing anti-inflammatory effects and improving insulin and PDX-1 gene expression, which are crucial for pancreatic function and diabetes management [3][4]