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In the preliminary screening phase, the standard battery of genotoxicity tests might be unable to identify tissue-specific carcinogens, if the test system lacks the enzymes needed to form the toxic metabolite, and certainly does not provide any information on the possible species specificity of the test compound (Brambilla and Martelli 2004

Chem Res Toxicol 15, 11791189

Vegetarian or vegan diets are not automatically deficient, but poorly planned versions can provide less methionine and creatine
