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Wnt/-catenin signaling

Haidar A, Tsoukas MA, Bernier-Twardy S, et al
In summary, by bolstering endothelial function and possibly mimicking exercise-like effects on the heart, MOTS-c shows promise as a factor that could contribute to cardiovascular well-being

But people can get blemishes from flu shots, so there is no direct correlation that B12 causes blemishes. Unfortunately though, theres no way to know beforehand if B12 will cause a breakout