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(2014) reported significant reductions of activity during a memory encoding task in 10 subjects with early PD and APOE4 when compared to APOE2 and APOE3 carriers (Nombela et al., 2014)
Included amongst these KG-dependent dioxygenases that are inhibited by L2HG and D2HG are Jumonji domain-containing histone-lysine demethylases (Jmj-KDMs), that demethylate histones, as well as TETs, which demethylate 5-methyl-cytosine (5mC) residues in genomic DNA
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doi: 10.1038/nm.1960 149 DuncanSEGaoSSarheneMCoffieJWLinhuaDBaoXet al
