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In plants, glutathione S-conjugates are either sequestered in the vacuole (Coleman et al., 1997

The regulation of IL-6 implicates skeletal muscle as an integrative stress sensor and endocrine organ

Mitophagy impairment also affects cell fate decisions

Ultimately, after being released into the synaptic space, it is taken up by surrounding neurons and glia, resulting in neurodegeneration (Peng et al., 2018)
