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Description
For sequenced PDX transcriptomes, reads were aligned to human genome reference (hg19) and annotated with the human GENCODE (v19) database using the STAR tool (v.2.7.5a) 56
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Images were acquired and analyzed using the Odyssey Infrared Imaging System (Li-COR Biosciences)
IGF1R activation via DES(1-3) IGF-1 induced a 2.8-fold increase in S-phase cell population, reversing the 50% S-phase reduction produced by gefitinib monotherapy
