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Clinical studies have found that zinc supplementation helps improve glycemic control and also reduces the severity of diabetic neuropathy (Jayawardena 2012

In this context, PH20, I-BET151, and PXS-5153A may indirectly counteract thyroid-related fibrosis by degrading ECM, inhibiting profibrotic signaling, or reducing collagen crosslinking

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In the case of L-carnitine, the evidence is mixed : some trials and reviews find modest changes in certain indicators, while others show no relevant differences