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Through the inhibition of ACC and the activation of MCD, MAPK diminishes malonyl-CoA levels, leading to a reduction in fatty acid synthesis and an increase in fatty acid catabolism ( Nuclear factor erythroid 2-related factor 2 (Nrf2) is a critical transcription factor in cellular antioxidant responses (Sul and Ra, 2021)
Therefore, pyridoxin supplementation would have beneficial effects on migraine patients due to the role of vascular functions in migraine attacks (54, 55)
Individual metabolic variability significantly influences treatment response
J Neurochem 114:820831
