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A regimen combining a loading dose and no loading dose, involving administration every three days for two weeks followed by weekly doses, appears to be the optimal approach for treating vitamin B12 deficiency in elderly patients.
10.1038/s41598-018-24917-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 70.McArdle PF, Whitcomb BW, Tanner K, Mitchell BD, Shuldiner AR, Parsa A
These can be specific or broad-spectrum pumps
