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2.10.1 Limitation of in-vitro model Despite their value in mechanistic research, in vitro models present several critical limitations that constrain their translational applicability (Blanchard et al., 2022)
Tablets and capsules used to be the only way to take supplements
The secretion of vasopressin is regulated in the hypothalamus by osmoreceptors which sense water and Na + concentration and stimulate increased vasopressin secretion when plasma osmolarity increases
Dai et al, 2020), which could explain favoring of nonmesodermal cell lineages in organoids upon loss of Nrf2 expression
