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Previous studies have shown that supplementation of vitamin D prevents acute respiratory tract infections (Martineau et al, 2017)
The murine lung microbiome changes during lung inflammation and intranasal vancomycin treatment
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Furthermore, the mechanistic understanding of metabolite-mediated epigenetic reprogramming continues to expand, with evidence showing that lactate-induced histone lactylation and itaconate-driven Nrf2 activation can establish and sustain an anti-inflammatory macrophage phenotype, opening avenues for durable immunomodulation (78, 82, 84)
