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doi: 10.1016/j.lpm.2022.104142 48 KozlowskiTAndreoniK

Symptoms of Biotin Deficiency Hair loss or alopecia, depression, lethargy, hallucinations, numbness and tingling in the hands and feet, a scaly, red rash around the eyes, nose and mouth, seizures, weakened immune system, increased risk of bacterial and fungal infections

Guidelines for the diagnosis and treatment of cobalamin and folate disorders British Society for Haematology

Contact with the bone usually indicates the needle contact with the wings of the sacrum or the iliac bone, superior to and near the greater sciatic notch
