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Science 368 , 8589 (2020)
By properly balancing endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) signaling, BPC-157 down-regulates destructive pro-inflammatory cytokines without neutralizing the acute, necessary oxidative signals needed to command cellular division 6
Despite these promnestic effect, the metabolism of sulfated neurosteroids, such as PregS by sulfatases, coupled with limited transport across the BBB, has impeded the development of this compound as a novel therapeutic
