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Description
The first ORF encodes four non-structural proteins required for RNA replication

A deep joint infection in a reconstructed or replaced knee is one of the most serious complications in orthopaedics

Perhaps this has to do with the specific discrete mutational event causing their development

Phase I/II trial of encorafenib, cetuximab, and nivolumab in patients with microsatellite stable (MSS), BRAFV600E metastatic colorectal cancer
