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The hydrolytic activity of CEL towards water-insoluble triglycerides and cholesteryl esters requires its activation by bile salts, whereas, the activity of the enzyme in hydrolyzing water soluble substrates, such as lysophospholipids, is not dependent on bile salt activation

However, in addition to neurotoxicity associated with A peptide and pTau, other key determinants of the neurodegenerative process need to be included in the list of the main causative factors of AD

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But these side effects have been identified in case-based studies