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The five most prevalent neurodegenerative disorders (NDD) Alzheimers disease (AD), Parkinsons disease (PD), Huntingtons disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently lack curative interventions (4)

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Efforts to replace feeder layers with alternatives such as B27 or small molecule inhibitors have shown potential but require long culture periods (taking up to 37 days) (Zhu, Gao et al

The distinct actions of Myo-Ins and Mdivi-1 indicate that the Myo-Insdependent potentiation of ATP-mediated Ca signalling does not primarily depend on mitochondrial fission inhibition, consistent with a mechanism acting at the level of PIP metabolism or IP-mediated signalling, rather than through changes in mitochondrial structure
