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Thus, absence of GPx1 in knockout mice was found to augment neuronal damage in the middle cerebral artery occlusion ischemia-reperfusion (MCAO) model of stroke, with increased infarct volume and increased apoptosis in brains of GPx1 / mice compared with wildtype mice [106]

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The standard protocol involves 5 to 10 mg daily via subcutaneous injection for 10 to 20 consecutive days, repeated once or twice per year with 4 to 6 months between cycles

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