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Receptor-mediated transcytosis is the primary physiological pathway for transporting biological macromolecules across the BBB
Iron is a cofactor of several enzymes and an important component of the Fe-S cluster, participating in insulin secretion as well as in the proliferation and differentiation of cells
The caveat to that is that the presence of some of those substances will only result in an adverse analytical finding if present at or above a certain specified concentration
J Alzheimer's Dis 40:519529 Gu M, Owen AD, Toffa SE, Cooper JM, Dexter DT, Jenner P, Marsden CD, Schapira AH (1998) Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases
