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**Maintenance Dose:** 1 mg (1 mL) intramuscularly or subcutaneously, administered once a month, or as directed by a healthcare professional

The most common drug related adverse events reported in adult subjects treated with 2.5-10 g hydroxocobalamin intravenously were reddening of the urine or skin, cutaneous or pustular/papular rash, and an increase in blood pressure (Fortin et al., 2006

After 3 h for cell attachment, medium was exchanged to Sera Plus-free medium and cells were allowed to adjust for 16 h before treatment

In this case, as also stated by the authors, the supplementation could be efficacious only if it is going to be prophylactically used prior to an H5N1 influenza infection