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There are currently no randomized clinical trials specifically evaluating lycopene in inflammatory rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, or psoriatic arthritis

doi: 10.1016/j.biochi.2013.02.010 139 KiketeSLuoLJiaBWangLOndiekiGBianY

doi: 10.1016/0163-7258(91)90076-x

particularly, there is a reordering of six residues at the C-terminus of the large subunit with suggested role in enzyme catalysis (Lin et al., 2014)
