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These amyloid structures are normally broken down by lysosomal proteases as part of autophagy, a cellular waste removal mechanism that works together with the glymphatic system [24]

Formalin-fixed eyeballs were embedded in paraffin and sectioned into 5 m thick slices for H&E and PAS staining

however, even within these frameworks, heterogeneity within recruited populations remains a significant limitation

Several studies have revealed that melatonin is able to induce the expression of GSH and various antioxidant enzymes such as catalase, SOD, and GPx, as well as to activate the Nrf2 signalling pathway (Swiderska-Koacz et al., 2006