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As stated by the authors of a 2019 review on BPC-157 and soft-tissue healing, Future studies should focus on elucidating as to whether the reported benefits of BPC-157 extend beyond research animals.9 Also, there are some side effects associated with the peptide

[2] Absolute contraindications include known or suspected carcinoma of the prostate or male breast, pregnancy or breastfeeding, hypersensitivity to testosterone or formulation components, and serious hepatic, renal, or cardiac impairment that could be exacerbated by fluid retention

Hence, cobalamin-related remethylation disorders are usually treated by intramuscular (IM) injections at an individually titrated, minimum effective dose

This makes BPC-157s preclinical safety evaluation more dependent on empirical data which, as noted above, is limited in scope than on mechanism-based safety predictions