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Colburn P'20 Jana Colecchia P'22 Joseph F

Dietary surveys in the US indicate that the average adult intake of LA ranges from 17 to 20 g/day for men and 12 to 13 g/day for women (78)

In mouse studies, spermidine treatment resulted in decreased IL-17 levels in the corneas and lacrimal glands, stabilizing the tear film and mitigating ocular surface inflammation ( 4.5.4 Possible side effects and potential health risks While spermidine offers therapeutic benefits, its use in treating ocular conditions must be approached with caution due to potential cytotoxic effects

Aceptado: 12-05-2011 INTRODUCTION Melanosis is a term given to lesions showing an increased number of normal melanocytes confined to the basal layer of the squamous epithelium in which the pigment melanin is confined and on visual inspection it may have an appearance similar to malignant melanoma (1, 2)