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In the projects related to developmental angiogenesis, our models include the murine mammary gland and the chicken embryo

Given that the cellular thiol network, including GSH, involves crosstalk between the cytosol and organelles, we selected two of the dysregulated enzymes, which had been identified by 2D electrophoresis, with important roles in mitochondrial function, i.e., Aco2 and mitochondrial creatine kinase (mtCK) (Fig

EGCG was also of benefit in the treatment of lung fibrotizing diseases which result from chronic activation of NF-B and overproduction of pro-inflammatory cytokines and proteolytic enzymes, depletion of antioxidant system Nrf2, activation of growth factors, increased expression of fibrogenic and angiogenic factors leading to elevated MMPs, smooth muscle actin (SMA), collagen, etc

Yang L, Wang Y, Li Z, Wu X, Mei J, Zheng G