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Canadian Journal of Chemistry

L-Carnitine is a nitrogenous compound essential for energy production and fat metabolism

Carnitine has been reported to exert a beneficial effect on synaptic plasticity through a range of mechanisms, including its antioxidant and anti-inflammatory effects, as well as its capacity to regulate the expression of synaptic plasticity-related biomarkers [100,101,102]

Affecting approximately 50% of patients with diabetes, DN is predominantly characterized by distal symmetric polyneuropathy, leading to sensory loss, pain, and motor dysfunction, often resulting in diabetic foot ulcers and lower-limb amputations